Neuigkeiten 2017_02 emotionaler Stress verursacht kardiovaskuläre Erkrankungen - The Lancet
Jetzt ist der Ort im Hirn gefunden, der bei emotionalem Stress [auch bei der Arbeit] über Aktivierung der Knochenmarksaktivität und Induktion arterieller Entzündung kardiovaskuläre Erkrankungen verursacht:
Die Amygdala - ein Teil des Limbischen Systems.
Informationen auf Neuroscience online
Bild>Quelle: https://de.wikipedia.org/wiki/Datei:Amygdala.gif
Relation between resting amygdalar activity and cardiovascular events: a longitudinal and cohort study
The Lancet, In Press, Corrected Proof, Available online 12 January 2017
Autoren: Ahmed Tawakol, Amorina Ishai, Richard AP Takx, Amparo L Figueroa, Abdelrahman Ali, Yannick Kaiser, Quynh A Truong, Chloe JE Solomon, Claudia Calcagno, Venkatesh Mani, Cheuk Y Tang, Willem JM Mulder, James W Murrough, Udo Hoffmann, Matthias Nahrendorf, Lisa M Shin, Zahi A Fayad, Roger K Pitman
http://www.sciencedirect.com/science/article/pii/S0140673616317147
Summary
Background - Emotional stress is associated with increased risk of cardiovascular disease. We imaged the amygdala, a brain region involved in stress, to determine whether its resting metabolic activity predicts risk of subsequent cardiovascular events.
Methods - Individuals aged 30 years or older without known cardiovascular disease or active cancer disorders, who underwent 18F-fluorodexoyglucose PET/CT at Massachusetts General Hospital (Boston, MA, USA) between Jan 1, 2005, and Dec 31, 2008, were studied longitudinally. Amygdalar activity, bone-marrow activity, and arterial inflammation were assessed with validated methods. In a separate cross-sectional study we analysed the relation between perceived stress, amygdalar activity, arterial inflammation, and C-reactive protein. Image analyses and cardiovascular disease event adjudication were done by mutually blinded researchers. Relations between amygdalar activity and cardiovascular disease events were assessed with Cox models, log-rank tests, and mediation (path) analyses.
Findings - 293 patients (median age 55 years [IQR 45·0–65·5]) were included in the longitudinal study, 22 of whom had a cardiovascular disease event during median follow-up of 3·7 years (IQR 2·7–4·8). Amygdalar activity was associated with increased bone-marrow activity (r=0·47; p<0·0001), arterial inflammation (r=0·49; p<0·0001), and risk of cardiovascular disease events (standardised hazard ratio 1·59, 95% CI 1·27–1·98; p<0·0001), a finding that remained significant after multivariate adjustments. The association between amygdalar activity and cardiovascular disease events seemed to be mediated by increased bone-marrow activity and arterial inflammation in series. In the separate cross-sectional study of patients who underwent psychometric analysis (n=13), amygdalar activity was significantly associated with arterial inflammation (r=0·70; p=0·0083). Perceived stress was associated with amygdalar activity (r=0·56; p=0·0485), arterial inflammation (r=0·59; p=0·0345), and C-reactive protein (r=0·83; p=0·0210).
Interpretation - In this first study to link regional brain activity to subsequent cardiovascular disease, amygdalar activity independently and robustly predicted cardiovascular disease events. Amygdalar activity is involved partly via a path that includes increased bone-marrow activity and arterial inflammation. These findings provide novel insights into the mechanism through which emotional stressors can lead to cardiovascular disease in human beings.
Ergänzungen
Juli 2018 -
Stress erhöht die Wahrscheinlichkeit einer Immunstörung = der Wahscheinlichkeit, an einer Autoimmunerkrankung zu erkranken:
Song H, Fang F, Tomasson G, et al. Association of stress-related disorders with subsequent immune disease. JAMA 2018; 319:2388-400. https://jamanetwork.com/journals/jama/article-abstract/2685155
August 2018 -
Forschungsprojekt "Krankheit durch Stress - Rolle des Immunsystems" am Institut für Arbeitsforschung Dortmund IfaDo https://www.ifado.de/immunologie/warum-stress-krank-macht-neue-forschungsgruppe-am-ifado/